Colon Polyps: ICD 10 Coding AAPC Knowledge Center Classification of HES diagnoses using ICD 10 Download Scientific Diagram Melanosis coli: Symptoms, causes, treatment, and more Melanosis coli is dark brown black pigmentation of colorectal mucosa associated with chronic use of laxatives containing anthraquinone. Examples of such laxatives include senna and rhubarb derivatives. Clinical Importance: There is no association “Melanosis” in the small and large intestine This is how laxative abuse affects colon resulting in melanosis coli .