Aesthetic Depigmentation of Gingival Smoker's Melanosis Using Carbon Dioxide Lasers Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review This is a picosecond laser treatment of labial melanotic macules on the gingiva. Note the green flashes of the 532 nm laser as well as the immediate tissue whitening of the treated area. This Pathology Outlines Melanotic macule An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic Oral Melanotic Macule An Unusual Occurrence In Gingiva Journal of Health and Allied Sciences NU