Oral Melanotic Macule: Symptoms and Treatment Skinsight Differential Diagnosis of Pigmented Lesions in the Oral Mucosa: A Clinical Based Overview and Narrative Review Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Pigmented macular lip lesion Clinical Advisor This lovely patient was thrilled with her beautiful result after laser treatment of oral melanotic macules. I share this case to educate: laser treatment requires accurate diagnosis, an understanding Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule.