Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health PDF] Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma Semantic Scholar Tylenol And Glutathione Invigor Medical Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health