Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology Hidden Risks of NSAIDs, Tylenol, Steroids & Opioids Denver Sports and Holistic Medicine A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy