Melanosis coli is dark brown black pigmentation of colorectal mucosa associated with chronic use of laxatives containing anthraquinone. Examples of such laxatives include senna and rhubarb derivatives. Clinical Importance: There is no association Melanosis coli: Harmless pigmentation? A case control retrospective study of 657 cases PLOS One Brilliant Colonic Adenoma in Melanosis Coli Indian Journal of Surgery Springer Nature Link ICD 10 CM TRAINING July 16, 2013 ulcerative colitis with rectal bleeding ICD 10 code difference Bring Awareness to Crohn's and Colitis in December AAPC Knowledge Center